The conceptual model of sustainable development of the rubal sector

On the one hand, the relevance of the studied issue is determined by growing lag of rural territorial units in socioeconomic development, and one the other by their significance in such important aspects of the country, as ensuring food supply security, preservation of the available land, production, ecological, demographic and human potential. The aim of the article is to develop the conceptual model of sustainable development of rural areas, which is based on the system of indicators of quality of living of rural population. The leading method for studying this issue is modeling, which allows to consider it as a targeted and organized process of formation of the concept of sustainable development of the rural sector of the regional economy using the example of the studies of experience of sustainable development of the Kinel-Cherkassky municipal district of the Samara region. The results: the analysis of consistence and tendencies of development of agrarian potential of rural areas of the Samara region was carried out for the purpose of implementation of the conceptual model of sustainable development and assessment of further prospects in the production sphere of the village; the main reasons for disproportion in sustainable development of rural areas of the Samara region are identified. The materials of this article can be used for theoretical conclusions, methodological developments and working knowledge in activities of bodies of the regional government and local self-government when developing the concept and programs of sustainable development of rural municipalities. © 2016 Belyaeva et al

Pedagogical conditions of primary drug abuse prevention among students of a higher education institution

The relevance of the researched problem is caused by the fact that being one of the least adapted and socially unprotected groups, young people bear the impress of general social uncertainty, lack of confidence and uneasiness, as a result of it, drug addiction problems among young people are pushed into the forefront among social-pedagogical and psychological-pedagogical problems. The purpose of the presented article consists in theoretical reasons, development experimental and research check of a complex of the pedagogical conditions providing efficiency of primary prevention of drug addiction among students of a higher education institution. The leading method to a research of this problem is the modeling method that enables to consider this problem as a purposeful and organized process of creation of the pedagogical conditions necessary for effective primary prevention of drug addiction among students of a higher education institution. The complex of the pedagogical conditions providing efficiency of process of primary drug abuse prevention is presented in the article. It consists of the pedagogical analysis of the reasons of a drug abuse, detection of specifics of a drug abuse of youthful age, the choice and use of the methods and agents of primary prophylaxis of a youth drug abuse, development of a special course for training of specialists which are carrying out activities for prophylaxis of the drug habit at educational organizations. The complex of pedagogical conditions is focused on the process organization of drug abuse prevention among students and focused on development of methodical ensuring process of training of the teachers who are carrying out activities for drug abuse prevention in educational organizations. The materials of article can be useful to teachers of higher education institutions and colleges participating in the organization and carrying out preventive measures of a drug addiction, and also to the listeners, graduates of military academies, and practical staffof Department of Internal Affairs of the Russian Federation who are interested in drug addiction problems. © Authors

High Resolution Infrared Spectroscopy in Support of Ozone Atmospheric Monitoring and Validation of the Potential Energy Function

The first part of this review is a brief reminder of general information concerning atmospheric ozone, particularly related to its formation, destruction, observations of its decrease in the stratosphere, and its increase in the troposphere as a result of anthropogenic actions and solutions. A few words are said about the abandonment of the Airbus project Alliance, which was expected to be the substitute of the supersonic Concorde. This project is over due to the theoretical evaluation of the impact of a fleet in the stratosphere and has been replaced by the A380, which is now operating. The largest part is devoted to calculations and observations of the transitions in the infrared range and their applications for the atmosphere based both on effective models (Hamiltonian, symmetry rules, and dipole moments) and ab initio calculations. The complementarities of the two approaches are clearly demonstrated, particularly for the creation of an exhaustive line list consisting of more than 300,000 lines reaching experimental accuracies (from 0.00004 to 0.001 cm−1) for positions and a sub percent for the intensities in the 10 microns region. This contributes to definitively resolving the issue of the observed discrepancies between line intensity data in different spectral regions: between the infrared and ultraviolet ranges, on the one hand, and between 10 and 5 microns on the other hand. The following section is devoted to the application of recent work to improve the knowledge about the behavior of potential function at high energies. A controversial issue related to the shape of the potential function in the transition state range near the dissociation is discussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: The activities of S.M. and E.S. were supported by the Ministry of Science and Higher Education of the Russian Federation (V.E. Zuev Institute of Atmospheric Optics SB RAS); the work of S.M. was also supported by Ural Federal University

Highly wear-resistant and biocompatible carbon nanocomposite coatings for dental implants

Diamond-like carbon coatings are increasingly used as wear-protective coatings for dental implants, artificial joints, etc. Despite their advantages, they may have several weak points such as high internal stress, poor adhesive properties or high sensitivity to ambient conditions. These weak points could be overcome in the case of a new carbon nanocomposite coating (CNC) deposited by using a C60 ion beam on a Co/Cr alloy. The structure of the coatings was investigated by Raman and XPS spectroscopy. The wear resistance was assessed by using a reciprocating tribotester under the loads up to 0.4 N in both dry and wet sliding conditions. Biocompatibility of the dental implants was tested in vivo on rabbits. Biocompatibility, bioactivity and mechanical durability of the CNC deposited on a Co/Cr alloy were investigated and compared with those of bulk Co/Cr and Ti alloys. The wear resistance of the CNC was found to be 250e650 fold higher compared to the Co/Cr and Ti alloys. Also, the CNC demonstrated much better biological properties with respect to formation of new tissues and absence of negative morphological parameters such as necrosis and demineralization. Development of the CNC is expected to aid in significant improvement of lifetime and quality of implants for dental applications

Novel data about association of the functionally significant polymorphisms of the MMP9 gene with exfoliation glaucoma in the caucasian population of Central Russia

This study aimed to investigate the role of functionally significant polymorphisms of the MMP1, MMP3, and MMP9 genes in the development of exfoliation glaucoma in the Caucasian population of Central Russi

2-(4-Chloro­benzo­yl)-1-(diamino­methyl­ene)hydrazinium chloride monohydrate

In the cation of the title compound, C8H10ClN4O+·Cl−·H2O, the guanidinium group is planar (maximum deviation = 0.0001 Å) and nearly perpendicular to carboxamide group, making a dihedral angle of 87.0 (3)°. The N atoms of the guanidine fragment have a planar trigonal configuration and the N atom of the carboxamide group adopts a pyramidal configuration. In the crystal structure, inter­molecular N—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds link the cations, anions and water mol­ecules into layers parallel to the bc plane

Efficacy of genetically engineered biological agents in the treatment of uveitis associated with rheumatic diseases in children

The efficiency of incorporating genetically engineered biological agents (GEBAs) into a combination treatment regimen for rheumatic diseases (RD) (juvenile idiopathic arthritis, Behcet's disease) in relation to associated uveitis of varying severity was studied in 92 children aged 2 to 17 years. The follow-up lasted 1.5 to 49 months. Twenty-three patients took consecutively 2 to 5 GEBAs. When infliximab was used, remission of uveitis occurred in 21% of 38 children and the disease activity and/or recurrence rates reduced in an additional 21%. These were in 45 and 38.6% of 44 patients on adalimumab (ADA) and in 27.8 and 27.8% of 18 patients on abatacept, respectively. There was an association of the efficiency of therapy with the severity of uveitis at the start of treatment. The use of ADA induced a steady remission of panuveitis resistant to therapy with glucocorticoids and cyclosporine in both patients with Behcet's disease. One of 4 rituximab-treated patients achieved a steady remission. Tocilizumab therapy caused an exacerbation of uveitis in 1 patient. The postoperative period showed no inflammatory complications in most cases (37 operations, 26 eyes, 20 patients). No local adverse reactions were seen; systemic reactions occurred in 14% of the patients, this caused GEBAs to be discontinued in 7%. There is evidence for a need for further investigations into the efficacy of GEBAs in RD-associated uveitis in children in order to define success criteria, differentiated indications, and therapy regimens

Educational migration as a phenomenon of the modern world

В статье представлена образовательная миграция в условиях современного развития нашей страны.The article presents educational migration in the modern development of our country

IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES

Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme

Роль микробиома верхних дыхательных путей в здоровье человека: барьерная функция

The human respiratory tract is a complex system characterized by a series of niches colonized with specific microbial communities. Until recently, researchers were mostly interested in lung microbiomes associated with acute and chronic infections. The upper respiratory tract microbiota has gained attention during COVID-19 (COronaVIrus Disease 2019) pandemic because it was suspected to influence the course and the outcome of viral infections. Aim. In this two-part review (see part 1, Pul’monolog;iya. 2022; 32 (5): 745-754), we summarize current knowledge of the microbial communities at each upper respiratory tract location, considering the proposed barrier function of the respiratory microbiome. Conclusion. Based on the evidence presented in this review, we can see how the respiratory microbiome is involved in the pathogenesis of viral respiratory infections, including SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2).Дыхательные пути человека представляют собой сложную систему с собственным микробным профилем. До недавнего времени основной интерес научного сообщества вызывали микробные сообщества легких, ассоциированные с различными заболеваниями. В свете пандемии COVID-19 (COronaVIrus Disease 2019) внимание сфокусировалось на микробиоте верхних дыхательных путей (ВДП), которая, как предполагается, может являться одним из факторов, оказывающих влияние на течение вирусных инфекций. Целью обзора, состоящего из 2 частей, явились сбор и анализ известной к настоящему моменту информации о микробных сообществах каждого из отделов ВДП. Часть 2-я посвящена предположительной барьерной функции респираторной микробиоты. Заключение. Приведенные данные позволяют рассматривать микробные сообщества дыхательных путей в качестве участников патогенеза респираторных вирусных инфекций, в т. ч. SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2)